Disulfide bridges strongly constrain the native structure of many proteins and predicting their formation is therefore a key sub-problem of protein structure and function 9002nc inference.Most recently proposed approaches for this prediction problem adopt the following pipeline: first they enrich the primary sequence with structural annotations, se
We consider the problem of finding checkerboard copulas for modeling multivariate distributions.A checkerboard copula is a distribution with a corresponding density defined almost everywhere by a step function on an m-uniform subdivision of the unit hyper-cube.We develop optimization procedures for finding copulas defined by multiply-stochastic mat
Attempts at ′preservation via displacement′ are an extreme click here manifestation of the ′fortress′ or an exclusionary conservation paradigm, support for which has increased lately due to escalating conservation threats.While the policies and processes emanating from this paradigm have produced positive conservation ou
Effective approach/avoidance goal pursuit is critical for here attaining long-term health and well-being.Research on the neural correlates of key goal pursuit processes (e.g., motivation) has long been of interest, with lateralization in prefrontal cortex being a particularly fruitful target of investigation.However, this literature has often been